Alternatives to scarce Matrigel and why they are needed.
Alternatives to scarce Matrigel and why they are needed. Overlay

Alternatives to scarce Matrigel and why they are needed.

Date: Wednesday June 1, 2022 | By: procoll
Matrigel, first developed over 35 years ago has been used in 2D and 3D cell culture, however due to supply limitations, inconsistency of biochemical and mechanical properties and potential for antigenicity, researchers are now looking to other biomaterials for structural support of their cultures. This ProColl white paper examines the reasons for Matrigel’s limitations and […]
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ProColl Research Grade Collagen Gelling Protocol – Cross linker free
ProColl Research Grade Collagen Gelling Protocol – Cross linker free Overlay

ProColl Research Grade Collagen Gelling Protocol – Cross linker free

Date: Wednesday June 1, 2022 | By: procoll
When using acid soluble collagen, pH neutralisation in buffered conditions causes the collagen molecules to become insoluble and aggregate to form a gel when the pH is neutral. This forms a weak gel and chemical cross-linking is recommended to produce a stiffer gel that is better suited to the cell growth application. When a higher […]
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ProColl Research Grade Collagen Gelling Protocol – Genipin Cross linker
ProColl Research Grade Collagen Gelling Protocol – Genipin Cross linker Overlay

ProColl Research Grade Collagen Gelling Protocol – Genipin Cross linker

Date: Wednesday May 11, 2022 | By: procoll
Often the application of collagen requires the production of a structure that is mechanically robust. This can be achieved through a process of cross-linking functional groups on the collagen molecules. When using acid soluble collagen, the collagen molecules become insoluble and aggregates to form a gel when the pH is increased. However, this is a […]
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ISO 13485 Coming Soon
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ISO 13485 Coming Soon

Date: Wednesday January 12, 2022 | By: procoll
We are excited to announce that we are working with BS Partnership Ltd to implement our quality management system for ISO 13485 compliance. The completion of this process will enable ProColl collagen to be integrated into medical devices. We expect to have a successful audit completed by the end of this summer.
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Structured Collagen Superior to Gelatin for Cell Culture
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Structured Collagen Superior to Gelatin for Cell Culture

Date: Tuesday January 11, 2022 | By: procoll
Research by Sheffield University using ProColl’s acid soluble collagen demonstrated its superior performance over gelatin for cell culture. Using ProColl’s collagen resulted in cells with significantly better levels of key bone-growth markers. Calcium content and DNA were significantly higher when cultured on ProColl’s collagen than gelatin. Also, significantly lower collagen production occurred since the closer-to-native […]
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The Danger Posed by Endotoxins
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The Danger Posed by Endotoxins

Date: Monday November 15, 2021 | By: procoll
Endotoxins unfortunately are often found as contaminants of protein products derived from bioprocesses and because of their strong biological effects at very low concentrations within the human body they are of extreme concern for clinicians and the pharmaceutical industry. In patients even in small quantities endotoxins can result in fever, inflammation, sepsis, tissue damage and […]
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