Data & Updates

ProColl Research Grade Collagen Gelling Protocol – Genipin Cross linker
Often the application of collagen requires the production of a structure that is mechanically robust. This can be achieved through a process of cross-linking functional groups on the collagen molecules. When using acid soluble collagen, the collagen molecules become insoluble and aggregates to form a gel when the pH is increased. However, this is a […]

ISO 13485 Coming Soon
We are excited to announce that we are working with BS Partnership Ltd to implement our quality management system for ISO 13485 compliance. Completion of this process will enable ProColl collagen to be integrated into medical devices. We expect to have a successful audit completed by the end of this summer.

Structured Collagen Superior to Gelatin for Cell Culture
Research by Sheffield University using ProColl’s acid soluble collagen demonstrated its superior performance over gelatin for cell culture. Using ProColl’s collagen resulted in cells which had significantly better levels of key bone-growth markers. Calcium content and DNA were significantly higher when cultured on ProColl’s collagen than on gelatin. Also, significantly lower collagen production occurred since […]

The Danger Posed by Endotoxins
Endotoxins unfortunately are often found as contaminants of protein products derived from bioprocesses and because of their strong biological effects at very low concentrations within the human body they are of extreme concern for clinicians and the pharmaceutical industry. In patients even in small quantities endotoxins can result in fever, inflammation, sepsis, tissue damage and […]